Why Wait?

Endocytosis: Why not wait to deubiquitinate?

Deubiquitination by the Fat facets protein - a regulator of photoreceptor differentiation during Drosophila eye development - has been found to activate endocytosis, while ubiquitination inhibits endocytosis. Surprisingly, this is the opposite effect that ubiquitination has on endocytosis of many plasma membrane proteins.

Palliative care: if it makes a difference, why wait?

With prognostic indicators at hand, toss a coin. Half of all patients with cancer might be predicted to die as a result of the disease within 5 years. Ask yourself whether an individual patient might die within a year, and you are likely to be incorrect in your estimate. But what is certain is that you will not be able to cure everyone. Palliative care offers patients and (note) their families ...

Why wait? Three mechanisms selecting for environment-dependent developmental delays.

Many species delay development unless particular environments or rare disturbance events occur. How can such a strategy be favoured over continued development? Typically, it is assumed that continued development (e.g. germination) is not advantageous in environments that have low juvenile/seedling survival (mechanism 1), either due to abiotic or competitive effects. However, it has not previous...

Early surgery in infective endocarditis: Why should we wait?

Abbreviations: ACC, American College of Cardiology; AHA, American Heart Association; ESC, European Society of Cardiology; ICH, Intracranial haemorrhage; IE, Infective endocarditis. ∗ Corresponding author at: Department of Cardiovascular Medicine, Henri-Mondor University Hospital, 51, avenue de Lattre-de-Tassigny, 94100 Créteil, France. E-mail address: julien.ternacle.hmn@gmail.com (J. Ternacle)...

Otolaryngology workforce planning: why we cannot wait for perfect data.